Small artery structure and function in hypertension

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Small artery structure and function in hypertension

It has been known for some considerable time that sustained hypertension changes the circulatory architecture both in the heart and blood vessels. The histopathological alterations are of considerable interest because once they have developed they appear to carry an adverse prognostic risk. In the heart it is apparent that there is hypertrophy. This extends also to the large- and medium-sized b...

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Prognostic significance of small-artery structure in hypertension.

BACKGROUND The presence of structural alterations in the microcirculation may be considered an important mechanism of organ damage; however, it is not currently known whether structural alterations of small arteries may predict fatal and nonfatal cardiovascular events. METHODS AND RESULTS One hundred twenty-eight patients were included in the present study. There were 59 patients with essenti...

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Reducing pulse pressure in hypertension may normalize small artery structure.

To investigate the relation between the small artery structure and different blood pressure parameters, spontaneously hypertensive rats were treated from 4 to 24 weeks of age (20 weeks in total) with five different antihypertensive therapies: two angiotensin converting enzyme inhibitors (perindopril and captopril), a calcium antagonist (isradipine), a beta-blocker (metoprolol), and a vasodilato...

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A microfluidic platform for probing small artery structure and function.

Although pathologic changes to the structure and function of small blood vessels are hallmarks of various cardiovascular diseases, limitations of conventional investigation methods (i.e. pressure myography) have prohibited a comprehensive understanding of the underlying mechanisms. We developed a microfluidic device to facilitate assessment of resistance artery structure and function under phys...

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Brief Review Small Artery Structure in Hypertension Dual Processes of Remodeling and Growth

A lthough the causes of high blood pressure vary, it / \ is becoming clear that sustained hypertension is -Z A . associated with changes in cardiovascular structure: left ventricular hypertrophy and increased wall thickness:lumen diameter (wall:lumen) ratio of the blood vessels. To some extent, these alterations are natural physiological responses and are protective. However, the risk of circul...

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ژورنال

عنوان ژورنال: Journal of Cellular and Molecular Medicine

سال: 2010

ISSN: 1582-1838,1582-4934

DOI: 10.1111/j.1582-4934.2010.01080.x